DOUBLE TEST (11-14 TEST)

Bilateral screening test or the 11-14 test, also known as the first trimester screening test for Down syndrome and trisomy 18 babies with chromosomal abnormalities, called a screening test to detect the very early stages of pregnancy.

This test to make a diagnosis as well as in all screening tests. Only fetuses at high risk for the disease, and diagnostic testing ensures that leads to accurate diagnosis in infants. In other words, there is evidence that the test abnormalities, such as high-risk infants demonstrate the risk was low does not guarantee that the baby is completely healthy.

The test is done between 11-14 weeks.



Blood sample from the mother of free β-hCG and PAPP-A (pregnancy-specific plasma protein-A, pregnancy associated plasma protein-A) measurement and fetal nuchal translucency measurement with ultrasound as a result values ​​are used.

Risk ratio 1/270 's to be on the terms of Down syndrome requires further investigation.

Among the advantages of Dual pregnancy test done at an earlier period, and in the event of an abnormal result is more diagnostic test option (chorionic villus sampling, amniocentesis early or late) to have the baby in the case of anomalous termination of pregnancy may be carried out in an earlier period.
In addition, the sensitivity triple test has been reported to be higher in comparison with. The most important disadvantage is that the test saptayamamasıdır neural tube defects.

Binary test:
Only used a combination of PAPP-A and free b-hCG 65'lerdedir% detection rate of Down syndrome.
b-hCG and PAPP-A is a combination of fetal nuchal translucency is used to reach around 85% detection rate of Down syndrome.

Measurement of the nasal bone (nasal bone):
Nasal bone and nasal bone ultrasound değenlendirilmesini ie by combining the two tests are assessing some of the centers. Nasal bone ultrasound increases the risk of trisomy are encountered. Because the nasal bone can be seen in 98% of normal fetuses between 11-14 weeks, only 2% of the visible. 70% of trisomy 21 fetuses the nasal bone can not be seen. Nasal bone was seen in 50% of fetuses with trisomy 18. Observed in 30% of fetuses with trisomy 13 the nasal bone.

Disruption of blood flow in the ductus venozusta:
Venozusta duct (located close to the heart of a blood vessel in the fetus) disruption of blood flow in the normal and in some studies to differentiate various kinds of fetuses with chromosomal abnormalities were used. 5% of chromosomally normal fetuses, 80% of trisomic fetuses found to be abnormal ductus venozusta blood akıımı.

You always need to pay attention to the point: Double, triple and quadruple test for sure that the baby will never show any abnormality or disability than normal, increased or not increased the risk of not only refers to the anomaly. Anomaly show us whether the method is exactly the amniocentesis or CVS or cordocentesis is. (Amniocentesis: mother's womb the baby's bladder water intake process) every time ultrasound abnormalities such as trisomy 21 or 18 unnoticeable. In addition, the normal emergence of these tests does not mean that the baby is definitely anomaly. There is a certain amount of these tests margins of error.